Modulating contact lens discomfort with anti-inflammatory approaches: A randomized controlled trial

Abstract

PURPOSE. To assess the efficacy of anti-inflammatory approaches, comprising a topical corticosteroid and omega-3 supplements, for modulating the inflammatory overlay associated with contact lens discomfort (CLD). METHODS. This randomized controlled trial involved 72 adults with CLD, randomized (1:1:1:1) to one of the following: placebo (oral olive oil), oral fish oil (900 mg/d eicosapentaenoic acid [EPA] þ 600 mg/d docosohexaenoic acid [DHA]), oral combined fishþflaxseed oils (900 mg/ dEPAþ 600 mg/d DHA þ 900 mg/d alpha-linolenic acid), or omega-3 eye-drops (0.025% EPA þ 0.0025% DHA four times per day [qid]) for 12 weeks, with visits at baseline, weeks 4 and 12. At week 12, participants who ..